LOCUS HB24_MOUSE 264 aa ROD 15-JUL-1998 DEFINITION H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, E-Q BETA CHAIN PRECURSOR (E-W17). TITLE Mumu_P20040 ACCESSION P20040 PID g122232 DBSOURCE swissprot: locus HB24_MOUSE, accession P20040; class: standard. created: Feb 1, 1991. sequence updated: Feb 1, 1991. annotation updated: Jul 15, 1998. xrefs: gi: 388046, gi: 199401, gi: 387451, gi: 199399, gi: 199400, gi: 90597 xrefs (non-sequence databases): HSSP P13760, PFAM PF00047, PFAM PF00969, PROSITE PS00290 SOURCE house mouse. ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 264) AUTHORS Vu,T.H., Tacchini-Cottier,F.M., Day,C.E., Begovich,A.B. and Jones,P.P. TITLE Molecular basis for the defective expression of the mouse Ew17 beta gene JOURNAL J. Immunol. 141 (10), 3654-3661 (1988) MEDLINE 89035495 REMARK SEQUENCE FROM N.A. COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. FEATURES Location/Qualifiers source 1..264 /organism="Mus musculus" /db_xref="taxon:10090" Region 1..26 /region_name="Signal" Protein 1..264 /product="H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, E-Q BETA CHAIN PRECURSOR" Region 27..121 /region_name="Domain" /note="EXTRACELLULAR BETA-1." Region 27..264 /region_name="Mature chain" /note="H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, E-Q BETA CHAIN." Bond bond(38,106) /bond_type="disulfide" /note="BY SIMILARITY." Site 46 /site_type="glycosylation" /note="POTENTIAL." Region 122..225 /region_name="Domain" /note="EXTRACELLULAR BETA-2." Bond bond(144,200) /bond_type="disulfide" /note="BY SIMILARITY." Region 226..246 /region_name="Transmembrane region" /note="POTENTIAL." Region 247..264 /region_name="Domain" /note="CYTOPLASMIC TAIL." ORIGIN 1 MVWLP RVPCV AAVIL LLTVL SPPVA LVRDS RPWFL EYCKS ECHFY NGTQR 51 VRFLK RYFYN LEENL RFDSD VGEFR AVTEL GRPDA ENWNS QPEIL EQKRA 101 AVDTY CRHNY EIFDN FLVRR RVEPT VTVYP TKTQP LEHHN LLVCS VSDFY 151 PGNIE VRWFR NGKEE KTGIV STGLV RNGDW TFQTL VMLET VPQSG EVYTC 201 QVEHP SLTDP VTVEW KAQST SAQNK MLSGV GGFVL GLLFL GAGLF IYFRN 251 QKGQS GLQPT GLLS // LOCUS HB2D_RAT 264 aa ROD 15-JUL-1999 DEFINITION RT1 CLASS II HISTOCOMPATIBILITY ANTIGEN, D-1 BETA CHAIN PRECURSOR. TITLE Rano_P18211 ACCESSION P18211 PID g122248 DBSOURCE swissprot: locus HB2D_RAT, accession P18211; class: standard. created: Nov 1, 1990. sequence updated: Nov 1, 1990. annotation updated: Jul 15, 1999. xrefs: gi: 57169, gi: 57170, gi: 92084 xrefs (non-sequence databases): HSSP P13760, PFAM PF00047, PFAM PF00969, PROSITE PS00290 SOURCE Norway rat. ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 264) AUTHORS Syha-Jedelhauser,J. and Reske,K. TITLE Sequence of rat cDNA clone pLR beta 112 coding for the RT1.D beta I chain JOURNAL Nucleic Acids Res. 18 (15), 4598 (1990) MEDLINE 90356406 REMARK SEQUENCE FROM N.A. STRAIN=LEWIS FAMILIARIS; TISSUE=BONE MARROW COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. [FUNCTION] INVOLVED IN THE PRESENTATION OF FOREIGN ANTIGENS TO THE IMMUNE SYSTEM. FEATURES Location/Qualifiers source 1..264 /organism="Rattus norvegicus" /db_xref="taxon:10116" Region 1..26 /region_name="Signal" Protein 1..264 /product="RT1 CLASS II HISTOCOMPATIBILITY ANTIGEN, D-1 BETA CHAIN PRECURSOR" Region 27..120 /region_name="Domain" /note="EXTRACELLULAR BETA-1." Region 27..264 /region_name="Mature chain" /note="RT1 CLASS II HISTOCOMPATIBILITY ANTIGEN, D-1 BETA CHAIN." Bond bond(42,106) /bond_type="disulfide" /note="BY SIMILARITY." Site 46 /site_type="glycosylation" /note="POTENTIAL." Region 121..215 /region_name="Domain" /note="EXTRACELLULAR BETA-2." Bond bond(144,200) /bond_type="disulfide" /note="BY SIMILARITY." Region 216..226 /region_name="Domain" /note="CONNECTING PEPTIDE." Region 227..248 /region_name="Transmembrane region" Region 249..264 /region_name="Domain" /note="CYTOPLASMIC TAIL." ORIGIN 1 MVWLA RDSCV AAVIL LLTVL SPPVA LVRDP TPRFL EQVKG ECHFY NGTQR 51 VRFLA RYIYN REEYT RFDSD VGEFR AVTEL GRPSA EYYNK QKEYM EQLRA 101 TVDTA CKHDY EISES FLVPR TVEPK VTVYP SKTQP LEHHN LLVCS VSDFY 151 PGSVE VRWFR NGEEE KDGLV STGLI RNGDW TFQLL VMLET VPQGG EVYTC 201 QVEHP SLPSP VRVEW KAQST SAQNK KMSGV GGIVL GLLFL GAGLF VYFRN 251 QKGQS GLQPT GLLN // LOCUS AAA42356 266 aa ROD 27-APR-1993 DEFINITION MHC class II DR-beta. TITLE Scab_AAA42356 ACCESSION AAA42356 PID g207710 DBSOURCE locus SQIDRB accession M97616.1 SOURCE tassel-eared squirrel. ORGANISM Sciurus aberti Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Rodentia; Sciurognathi; Sciuridae; Sciurinae; Sciurus. REFERENCE 1 (residues 1 to 266) AUTHORS Wettstein,P.J., Jin,L., Chakraborty,R. and States,J. TITLE The major histocompatibility complex of tassel-eared squirrels III. Divergence and diversity of DRA and DRB sequences in five subspecies JOURNAL Unpublished (1992) COMMENT Method: conceptual translation. FEATURES Location/Qualifiers source 1..266 /organism="Sciurus aberti" /isolate="A85" /sub_species="aberti" /db_xref="taxon:10007" /tissue_type="spleen" Protein 1..266 /product="MHC class II DR-beta" CDS 1..266 /coded_by="M97616.1:78..878" ORIGIN 1 MVGLC LRGSS CMAGL TLILM ALSLP LALAR DTRSR FLEQA TSECH FYNGT 51 QRVRF LERYF YNREE YVRFD SDVGE FRAVT ELGRP DAGYW NSQED LLERK 101 RAQVD TVCRH NYGVG QSFTV ERRVK PKVTV YPTKM QPLQH HNLLV CAVSG 151 FYPGH IEVRW FRNGQ EEEAG VVSTG LIQNG DWTFQ VLVML ETVPQ SGEVY 201 VCQVE HPSLM SPVTV EWRAQ SGSAQ SKMLS GVGGF VLGLL FLVLG MFIYY 251 RNQKG HSGLQ PTGLL S // LOCUS HB2O_PANTR 273 aa PRI 01-NOV-1990 DEFINITION CHLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO BETA CHAIN PRECURSOR (DR4/DW4,DPW4). TITLE Patr_P18467 ACCESSION P18467 PID g122262 DBSOURCE swissprot: locus HB2O_PANTR, accession P18467; class: standard. created: Nov 1, 1990. sequence updated: Nov 1, 1990. annotation updated: Nov 1, 1990. xrefs: gi: 176659, gi: 176660, gi: 321098 xrefs (non-sequence databases): HSSP P13760, PFAM PF00047, PFAM PF00969, PROSITE PS00290 SOURCE chimpanzee. ORGANISM Pan troglodytes Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Pan. REFERENCE 1 (residues 1 to 273) AUTHORS Kasahara,M., Klein,D. and Klein,J. TITLE Nucleotide sequence of a chimpanzee DOB cDNA clone JOURNAL Immunogenetics 30 (1), 66-68 (1989) MEDLINE 89307404 REMARK SEQUENCE FROM N.A. COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. FEATURES Location/Qualifiers source 1..273 /organism="Pan troglodytes" /db_xref="taxon:9598" Region 1..26 /region_name="Signal" Protein 1..273 /product="CHLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO BETA CHAIN PRECURSOR" Region 27..120 /region_name="Domain" /note="EXTRACELLULAR BETA-1." Region 27..273 /region_name="Mature chain" /note="CHLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO BETA CHAIN." Bond bond(41,105) /bond_type="disulfide" /note="BY SIMILARITY." Site 45 /site_type="glycosylation" /note="POTENTIAL." Region 121..214 /region_name="Domain" /note="EXTRACELLULAR BETA-2." Bond bond(143,199) /bond_type="disulfide" /note="BY SIMILARITY." Region 215..224 /region_name="Domain" /note="CONNECTING PEPTIDE." Region 225..245 /region_name="Transmembrane region" Region 246..273 /region_name="Domain" /note="CYTOPLASMIC TAIL." ORIGIN 1 MGSGW VPWVV ALLVN LTRLD SSMTQ GTDSP EDFVI QAKAD CYFTN GTEKV 51 QFVVR FIFNL EEYVR FDSDV GMFVA LTKLG QPDAE QWNSR LDLLE RSRQA 101 VDGVC RHNYR LGAPF TVGRK VQPEV TVYPE RTPLL HQHNL LHCSV TGFYP 151 GDIKI RWFLN GQEER ARVMS TGPIR NGDWT FQTVV MLEMT PELGH VYTCL 201 VDHSS LLSPV SVEWR AQSEY SWKKM LSGIA AFLLG LIFLL VGIVI QLRAQ 251 KGYVR TQMSG NEVSR AVLLP QSC // LOCUS HB2I_HUMAN 266 aa PRI 01-FEB-1991 DEFINITION HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-5 BETA CHAIN PRECURSOR. TITLE Hosa_P20039 ACCESSION P20039 PID g122254 DBSOURCE swissprot: locus HB2I_HUMAN, accession P20039; class: standard. created: Feb 1, 1991. sequence updated: Feb 1, 1991. annotation updated: Feb 1, 1991. xrefs: gi: 188229, gi: 307263, gi: 87700 xrefs (non-sequence databases): HSSP P13758, PFAM PF00047, PFAM PF00969, PROSITE PS00290 SOURCE human. ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 266) AUTHORS Tieber,V.L., Abruzzini,L.F., Didier,D.K., Schwartz,B.D. and Rotwein,P. TITLE Complete characterization and sequence of an HLA class II DR beta chain cDNA from the DR5 haplotype JOURNAL J. Biol. Chem. 261 (6), 2738-2742 (1986) MEDLINE 86140021 REMARK SEQUENCE FROM N.A. COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. FEATURES Location/Qualifiers source 1..266 /organism="Homo sapiens" /db_xref="taxon:9606" Region 1..29 /region_name="Signal" 1..266 Protein 1..266 /product="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-5 BETA CHAIN PRECURSOR" Region 30..124 /region_name="Domain" /note="EXTRACELLULAR BETA-1." Region 30..266 /region_name="Mature chain" /note="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-5 BETA CHAIN." Bond bond(44,108) /bond_type="disulfide" /note="BY SIMILARITY." Site 48 /site_type="glycosylation" /note="POTENTIAL." Region 125..227 /region_name="Domain" /note="EXTRACELLULAR BETA-2." Bond bond(146,202) /bond_type="disulfide" /note="BY SIMILARITY." Region 228..250 /region_name="Transmembrane region" Region 251..266 /region_name="Domain" /note="CYTOPLASMIC TAIL." ORIGIN 1 MVCLR LPGGS CMAVL TVTLM VLSSP LALAG DTRPR FLEYS TSECH FFNGT 51 ERVRF LDRYF YNQEE YVRFD SDVGE FRAVT ELGRP DEEYW NSQKD FLEDR 101 RAAVD TYCRH NYGVG ESFTV QRRVH PKVTV YPSKT QPLQH HNLLV CSVSG 151 FYPGS IEVRW FRNGQ EEKTG VVSTG LIHNG DWTFQ TLVML ETVPR SGEVY 201 TCQVE HPSVT SPLTV EWRAR SESAQ SKMLS GVGGF VLGLL FLGAG LFIYF 251 RNQKG HSGLQ PRGFL S // LOCUS AAA93105 266 aa PRI 29-MAR-1996 DEFINITION integral membrane protein. TITLE Gogo_AAA93105 ACCESSION AAA93105 PID g1237272 DBSOURCE locus GORMHCB301 accession M77153.1 SOURCE gorilla. ORGANISM Gorilla gorilla Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Gorilla. REFERENCE 1 (residues 1 to 266) AUTHORS Kasahara,M., Klein,D., Vincek,V., Sarapata,D.E. and Klein,J. TITLE Comparative anatomy of the primate major histocompatibility complex DR subregion: evidence for combinations of DRB genes conserved across species JOURNAL Genomics 14 (2), 340-349 (1992) MEDLINE 93052333 COMMENT Even though DNA was sequenced the entry is labeled mRNA since no intron sequences were provided. FEATURES Location/Qualifiers source 1..266 /organism="Gorilla gorilla" /isolate="Sylvia" /strain="Western lowland" /db_xref="taxon:9593" /cell_type="fibroblast" /sex="female" /tissue_type="skin" Protein 1..266 /product="integral membrane protein" CDS 1..266 /gene="DRB3*01" /coded_by="M77153.1:1..801" ORIGIN 1 MVCLK LPGGS CMAAL TVTLM VLSSP LALAG DTRPR FLELR KSECH FFNGT 51 ELVRY LDRYF HNQEE FVRFD SDVGE YRAVT ELGRP VAEYW NSQKD HLEQK 101 RGRVD NYCRH NYGVV ESFTV QRRVH PQVTV YPAKT QPLQH HNLLV CSVSG 151 FYPGS IEVRW FQNGQ EEKAG VVSTG LIQNG DWTFQ TLVML ETVPR SGEVY 201 TCQVE QPSVT SPLTV EWRAR SESAQ SKMLS GVGGF VLGLL FLGAG LFIYF 251 RSQKG HSGLQ PTGFL S // LOCUS AAB63308 266 aa PRI 17-JUL-1997 DEFINITION MHC class II DRB. TITLE Mamu_AAB63308 ACCESSION AAB63308 PID g561739 DBSOURCE locus MACDRBW201 accession L27742.1 SOURCE rhesus monkey. ORGANISM Macaca mulatta Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. REFERENCE 1 (residues 1 to 266) AUTHORS Lekutis,C. and Letvin,N.L. TITLE Biochemical and molecular characterization of rhesus monkey major histocompatibility complex class II DR JOURNAL Hum. Immunol. 43 (1), 72-80 (1995) MEDLINE 96053521 COMMENT Method: conceptual translation. FEATURES Location/Qualifiers source 1..266 /organism="Macaca mulatta" /db_xref="taxon:9544" /cell_line="B-LCL" Protein 1..266 /product="MHC class II DRB" sig_peptide 1..29 /codon_start=1 /product="MHC class II DRB" mat_peptide 1..266 /codon_start=1 /product="MHC class II DRB" CDS 1..266 /gene="DR-beta" /coded_by="L27742.1:1..801" ORIGIN 1 MVCLK LPGGS CMAAL TVTLM VLSSP LAVAG DTRPR FLGHA KSECH FFNGT 51 ERVRF LQRYI YNQEE FVRFD SDVGE FRAVT ELGRP DAESW NTRED ILERE 101 RAQVD TFCRH NYGVG ESFTV QRRVQ PKVTV YPAKT QPLQH HTLLV CSVSG 151 FYPGS IEVRW FRNGQ EEKAG VVSTG LIQNG DWTFQ TLVML ETVPQ SGEVY 201 TCQVE HPSVM SPLTV EWRAR SESAQ SKMLS GVGGF VLGLL FLGAG LFIYF 251 RNQKG HAGLQ PTGLL S // LOCUS C39797 265 aa PRI 12-JUL-1996 DEFINITION MHC class II histocompatibility antigen DR-beta chain DRB*03 precursor - pig-tailed macaque. TITLE Mane_C39797 ACCESSION C39797 PID g105032 DBSOURCE pir: locus C39797; summary: #length 265 #molecular-weight 29475 #checksum 2648; superfamily: class II histocompatibility antigen; immunoglobulin homology; PIR dates: 06-Dec-1991 #sequence_revision 06-Dec-1991 #text_change 12-Jul-1996. SOURCE pig-tailed macaque. ORGANISM Macaca nemestrina Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. REFERENCE 1 (residues 1 to 265) AUTHORS Zhu,Z.F., Vincek,V., Figueroa,F., Schonbach,C. and Klein,J. TITLE Mhc-DRB genes of the pigtail macaque (Macaca nemestrina): implications for the evolution of human DRB genes JOURNAL Mol. Biol. Evol. 8 (5), 563-578 (1991) MEDLINE 92114749 FEATURES Location/Qualifiers source 1..265 /organism="Macaca nemestrina" /db_xref="taxon:9545" Protein 1..265 /product="MHC class II histocompatibility antigen DR-beta chain DRB*03 precursor" ORIGIN 1 MVCLR LPGGS CMAPL TVTLM VLSSP LALAG DTRPH FLDQV KYECH FFNGT 51 ERVRL LGRHF YNQEE LVRFD SDVGE YRAVS ELGRP DAENL NARKD VLEQA 101 RAQVD TCRHN YGVVE SFTVQ RRVQP KVTVY PAKTQ PLQHH TLLVC SVNGF 151 YPGSI EVRWF RNGQE EKAGV ASTGL IQNGD WTFQT LVMLE TVPQS GEVYT 201 CQVEH PSVTS PLTVE WRARS ESAQS KMLSG VGGFV LGLLF LGAGL FIYFR 251 NQKGH AGLQP TGLLS // LOCUS B42621 266 aa PRI 07-FEB-1997 DEFINITION MHC class II histocompatibility antigen DR-beta chain 1 precursor (allele DRB1*0102) - cotton-top tamarin. TITLE Saoe_B42621 ACCESSION B42621 PID g627351 DBSOURCE pir: locus B42621; summary: #length 266 #molecular-weight 30058 #checksum 3483; genetic: #gene DRB1; superfamily: class II histocompatibility antigen; immunoglobulin homology; PIR dates: 09-Sep-1994 #sequence_revision 09-Sep-1994 #text_change 07-Feb-1997. SOURCE cotton-top tamarin. ORGANISM Saguinus oedipus Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; Platyrrhini; Callitrichidae; Saguinus. REFERENCE 1 (residues 1 to 266) AUTHORS Grahovac,B., Mayer,W.E., Vincek,V., Figueroa,F., O'hUigin,C., Tichy,H. and Klein,J. TITLE Major-histocompatibility-complex DRB genes of a New-World monkey, the cottontop tamarin (Saguinus oedipus) JOURNAL Mol. Biol. Evol. 9 (3), 403-416 (1992) MEDLINE 92261305 FEATURES Location/Qualifiers source 1..266 /organism="Saguinus oedipus" /db_xref="taxon:9490" Protein 1..266 /product="MHC class II histocompatibility antigen DR-beta chain 1 precursor (allele DRB1*0102)" Region 1..29 /region_name="domain" /note="signal sequence" Region 30..227 /region_name="domain" /note="extracellular" Site 48 /site_type="binding" /note="carbohydrate (Asn) (covalent)" Region 228..250 /region_name="domain" /note="transmembrane" Region 251..266 /region_name="domain" /note="intracellular" ORIGIN 1 MVCLR FPGGS CVAAL TVTLM VLSSP LALAG DTRPR FLEQA KAECH HFNGT 51 ERVRL LERYF YNQEE FVRFD SDVGE YRAVT ELGRP DEEYW NSRKD ILEQT 101 RAAVD TFCRH NYEIL ERFLV PRRVQ PKVTV YPAKT QPLQH HNLLV CSVSG 151 FYPGS IEVKW FRNDQ EEKAG VVSTG LIQNG DWTFQ TLVML ETVPQ SGEVY 201 ICQVE HASMT SPLTV QWRAR SESAQ SKMLS GVGGF VLGLL FLGAG LFIYF 251 RNQKG HSGLQ PTGLL S // LOCUS AAB65586 266 aa MAM 04-AUG-1997 DEFINITION MHC class II antigen. TITLE Feca_AAB65586 ACCESSION AAB65586 PID g2304943 DBSOURCE locus FCU51575 accession U51575.1 SOURCE cat. ORGANISM Felis catus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Carnivora; Fissipedia; Felidae; Felis. REFERENCE 1 (residues 1 to 266) AUTHORS Yuhki,N. and O'Brien,S.J. TITLE Nature and origin of polymorphism in feline MHC class II DRA and DRB genes JOURNAL J. Immunol. 158 (6), 2822-2833 (1997) MEDLINE 97211851 FEATURES Location/Qualifiers source 1..266 /organism="Felis catus" /db_xref="taxon:9685" /chromosome="B2" Protein 1..266 /product="MHC class II antigen" CDS 1..266 /gene="DRB" /coded_by="U51575.1:39..839" /note="Allele: DRB*0506; MhcFECA" ORIGIN 1 MVCLC FMGGS WMTAL MLILM MLSPP LAWAR GTSSH FLFLG KAECH YPNGT 51 ERVRL LDRYF YNGEE YVRFD SEVGE FRAVT ELGRP DAKYW NGQKD FMEQK 101 RAEVD TLCRH NYGVV DSFLV QRRVE PTVTV FPSKT QPLQH HNLLV CSVNG 151 FYPGH IEVKW FRNGQ EEETG VVSTG LIRNG DWTFQ TLVML ETVPQ SGEVY 201 TCHVE HPSRT SPITV EWRAQ SESAQ SKMLS GIGGF VLGLL FLVVG LFIYF 251 RNQKG HSGLQ PTGLL S // LOCUS HB2D_CANFA 266 aa MAM 15-JUL-1999 DEFINITION DLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-1 BETA CHAIN PRECURSOR. TITLE Cafa_P18470. ACCESSION P18470 PID g122244 DBSOURCE swissprot: locus HB2D_CANFA, accession P18470; class: standard. created: Nov 1, 1990. sequence updated: Nov 1, 1990. annotation updated: Jul 15, 1999. xrefs: gi: 164022, gi: 164023, gi: 321211 xrefs (non-sequence databases): HSSP P13760, PFAM PF00047, PFAM PF00969, PROSITE PS00290 SOURCE dog. ORGANISM Canis familiaris Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. REFERENCE 1 (residues 1 to 266) AUTHORS Sarmiento,U.M. and Storb,R. TITLE Nucleotide sequence of a dog DRB cDNA clone JOURNAL Immunogenetics 31 (5-6), 396-399 (1990) MEDLINE 90316610 REMARK SEQUENCE FROM N.A. COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. FEATURES Location/Qualifiers source 1..266 /organism="Canis familiaris" /db_xref="taxon:9615" Region 1..29 /region_name="Signal" Protein 1..266 /product="DLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-1 BETA CHAIN PRECURSOR" Region 30..124 /region_name="Domain" /note="EXTRACELLULAR BETA-1." Region 30..266 /region_name="Mature chain" /note="DLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-1 BETA CHAIN." Bond bond(44,108) /bond_type="disulfide" /note="BY SIMILARITY." Site 48 /site_type="glycosylation" /note="POTENTIAL." Region 125..227 /region_name="Domain" /note="EXTRACELLULAR BETA-2." Bond bond(146,202) /bond_type="disulfide" /note="BY SIMILARITY." Region 228..250 /region_name="Transmembrane region" Region 251..266 /region_name="Domain" /note="CYTOPLASMIC TAIL." ORIGIN 1 MVCLC FLGGS WMTAL MLILM VLNPP FAWAR DTPPH FLEVA KSECY FTNGT 51 ERVRF VERYI HNREE FVRFD SDVGE FRAVT ELGRP VAESW NGQKE ILEQE 101 RATVD TYCRH NYGVI ESFTV QRRVE PTVTV YPTKT QTLQH HNLLV CSVNG 151 FYPGH IEVRW LRNGQ EEEAG VVSTG LIRNG DWTFQ ILVML EIVPQ SGEVY 201 TCQVE HPSLT SPVTV EWRAQ SDSAQ SKMLS GIGGF VLGLL FLAVG LFIYF 251 RNQKG HSGLQ PTGLL S // LOCUS AAA91187 266 aa MAM 02-MAR-1996 DEFINITION MHC class II DLA DRB1 beta chain. TITLE Cafa_AAA91187 ACCESSION AAA91187 PID g1209893 DBSOURCE locus CFMHCDRB01 accession U47337.1 locus CFMHCDRB02 accession U47338.1 locus CFMHCDRB03 accession U47339.1 SOURCE dog. ORGANISM Canis familiaris Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Carnivora; Fissipedia; Canidae; Canis. REFERENCE 1 (residues 1 to 266) AUTHORS wagner,j l. TITLE Direct Submission JOURNAL Submitted (28-JAN-1996) John L. Wagner, Trans. Bio., FHCRC, 1124 Columbia St., Seattle, WA 98104, USA COMMENT Method: conceptual translation. FEATURES Location/Qualifiers source 1..266 /organism="Canis familiaris" /db_xref="taxon:9615" Protein 1..266 /product="MHC class II DLA DRB1 beta chain" CDS 1..266 /gene="DLA-DRB1" /coded_by="join(U47337.1:247..346,U47338.1:20..289, U47339.1:313..594,U47339.1:1346..1456,U47339.1:1920..1943, U47339.1:2460..2473)" /note="Allele: D14" ORIGIN 1 MVCLC FLGGS WMTAL MLILM VLNPP FAWAR DTPPH FLEML KSECY FTNGT 51 ERVRF VERYI HNREE NVRFD SDVGE YRAVT ELGRP DAEYW NPQKE LLERA 101 RAAVD TYCRH NYGVG ESFTV QRRVE PTVTV YPTKT QTLQH HNLLV CSVNG 151 FYPGH IEVRW LRNGQ EEEAG VVSTG LIRNG DWTFQ ILVML EIVPQ SGEVY 201 TCQVE HPSLT SPVTV EWRAQ SDSAQ SKMLS GIGGF VLGLL FLAVG LFIYF 251 RNQKG HSGLQ PTGLL S // LOCUS A39260 266 aa MAM 12-APR-1995 DEFINITION MHC class II histocompatibility antigen SLA-DR beta chain c - pig. TITLE Susc_A39260 ACCESSION A39260 PID g108349 DBSOURCE pir: locus A39260; summary: #length 266 #molecular-weight 30013 #checksum 6395; superfamily: class II histocompatibility antigen; immunoglobulin homology; PIR dates: 18-Oct-1991 #sequence_revision 18-Oct-1991 #text_change 12-Apr-1995. SOURCE domestic pig. ORGANISM Sus scrofa domestica Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Artiodactyla; Suiformes; Suina; Suidae; Sus. REFERENCE 1 (residues 1 to 266) AUTHORS Gustafsson,K., Germana,S., Hirsch,F., Pratt,K., LeGuern,C. and Sachs,D.H. TITLE Structure of miniature swine class II DRB genes: conservation of hypervariable amino acid residues between distantly related mammalian species JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (24), 9798-9802 (1990) MEDLINE 91088599 FEATURES Location/Qualifiers source 1..266 /organism="Sus scrofa domestica" /db_xref="taxon:9825" Protein 1..266 /product="MHC class II histocompatibility antigen SLA-DR beta chain c" ORIGIN 1 MACLC FSRGS WMAAL TVIVV VLSPP LALAR DIPPH FLHQL KFECH FFNGT 51 ERVRL LQRNC YNGEE YVRFD SDVGE YRAVT ELGRP DAKYR NSQKD LLEQR 101 RAAVD TYCRH NYRIL DTFLV PRRAE PTVTV YPAKT QPLQH HNLLV CSVTG 151 FYPGH VEVRW FRNGQ EEAAG VVSTG LIPNG DWTFQ TMVML ETVPQ SGEVY 201 SCRVE HPSLT SPVTV EWRAR SESAQ GKMMS GVGGF VLGLL FVAVG LFIYF 251 KNQKG RPALQ PTGLL S // LOCUS HB2J_MOUSE 264 aa ROD 01-OCT-1994 DEFINITION H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, I-E BETA CHAIN PRECURSOR. TITLE Mumu_P18469 ACCESSION P18469 PID g122257 DBSOURCE swissprot: locus HB2J_MOUSE, accession P18469; class: standard. created: Nov 1, 1990. sequence updated: Nov 1, 1990. annotation updated: Oct 1, 1994. xrefs: gi: 51536, gi: 51537, gi: 90378 xrefs (non-sequence databases): HSSP P13760, PFAM PF00047, PFAM PF00969, PROSITE PS00290 SOURCE house mouse. ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (residues 1 to 264) AUTHORS Acha-Orbea,H. and Scarpellino,L. TITLE Nonobese diabetic and nonobese nondiabetic mice have unique MHC class II haplotypes JOURNAL Immunogenetics 34 (1), 57-59 (1991) MEDLINE 91310089 REMARK SEQUENCE FROM N.A. STRAIN=NONOBESE DIABETIC / NOD; TISSUE=SPLEEN COMMENT ------------------------------------------------------------------- This SWISS-PROT entry is copyright. It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute. The original entry is available from http://www.expasy.ch/sprot and http://www.ebi.ac.uk/sprot ------------------------------------------------------------------. FEATURES Location/Qualifiers source 1..264 /organism="Mus musculus" /db_xref="taxon:10090" Region 1..31 /region_name="Signal" Protein 1..264 /product="H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, I-E BETA CHAIN PRECURSOR" Region 32..121 /region_name="Domain" /note="EXTRACELLULAR BETA-1." Region 32..264 /region_name="Mature chain" /note="H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, I-E BETA CHAIN." Bond bond(42,106) /bond_type="disulfide" /note="BY SIMILARITY." Site 46 /site_type="glycosylation" /note="POTENTIAL." Region 122..215 /region_name="Domain" /note="EXTRACELLULAR BETA-2." Bond bond(144,200) /bond_type="disulfide" /note="BY SIMILARITY." Region 216..225 /region_name="Domain" /note="CONNECTING PEPTIDE." Region 226..248 /region_name="Transmembrane region" Region 249..264 /region_name="Domain" /note="CYTOPLASMIC TAIL." ORIGIN 1 MVWLP RVPCV AAVIL LLTVL SPPVA LVRNS RPRFL EYSTS ECHFY NGTQR 51 VRFLE RYIYN REEYV RFDSD VGEYR AVTEL GRPDA EYWNS QPEIL EDARA 101 TVDTY CRHNY EIFDN FLVPR RVEPT VTVYP TKTQP LEHHN LLVCS VSDFY 151 PGNIE VRWFR NGKEE KTGIV STGLV RNGDW TFQTL VMLET VPQSG EVYTC 201 QVEHP SLTDP VTVEW KAQST SAQNK MLSGV GGFVL GLLFL GAGLF IYFRN 251 QKGQS GLQPT GLLS // LOCUS AAA93106 266 aa PRI 29-MAR-1996 DEFINITION integral membrane protein. TITLE Gogo_AAA93106 ACCESSION AAA93106 PID g1237275 DBSOURCE locus GORMHCB501 accession M77152.1 SOURCE gorilla. ORGANISM Gorilla gorilla Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Gorilla. REFERENCE 1 (residues 1 to 266) AUTHORS Kasahara,M., Klein,D., Vincek,V., Sarapata,D.E. and Klein,J. TITLE Comparative anatomy of the primate major histocompatibility complex DR subregion: evidence for combinations of DRB genes conserved across species JOURNAL Genomics 14 (2), 340-349 (1992) MEDLINE 93052333 COMMENT Even though DNA was sequenced the entry is labeled mRNA since no intron sequences were provided. FEATURES Location/Qualifiers source 1..266 /organism="Gorilla gorilla" /isolate="Sylvia" /strain="Western lowland" /db_xref="taxon:9593" /cell_type="fibroblast" /sex="female" /tissue_type="skin" Protein 1..266 /product="integral membrane protein" CDS 1..266 /gene="DRB5*0101" /coded_by="M77152.1:1..801" ORIGIN 1 MVCLK LPGGS YMAVL TVTLM VLSSP LALAG DTRPR FLKQD KYECH FFNGT 51 ERVRY LHRDI YNQEE DLRFD SDVGE YRAVT ELGRP DAEYW NSQKD VLEDE 101 RASVD TYCRH NYGVV ESFTV QRRVE PKVTV YPART QTLQH HNLLV CSVNG 151 FYPGS IEVRW FRNGQ EEKAG VVSTG LIQNG DWTFQ ILVML ETVPQ SGEVY 201 TCQVD HPSVT IPLTV EWRAQ SESAQ SKMLS GVGGF VLGLL FLGAG LFIYF 251 KNQKG HSGLH PTGLV S // LOCUS B27618 266 aa PRI 27-FEB-1997 DEFINITION MHC class II histocompatibility antigen HLA-DR beta 1 chain DR16 precursor - human. TITLE Hosa_B27618 ACCESSION B27618 PID g87120 DBSOURCE pir: locus B27618; summary: #length 266 #molecular-weight 29996 #checksum 6922; genetic: #gene GDB:HLA-DRB1 ##cross-references GDB:120642 #map_position 6p21.3-6p21.3; superfamily: class II histocompatibility antigen; immunoglobulin homology; PIR dates: 08-Mar-1989 #sequence_revision 08-Mar-1989 #text_change 27-Feb-1997. SOURCE human. ORGANISM Homo sapiens Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 266) AUTHORS Liu,C.P., Bach,F.H. and Wu,S.K. TITLE Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes JOURNAL J. Immunol. 140 (10), 3631-3639 (1988) MEDLINE 88199016 REMARK Erratum:[J Immunol 1990 Feb 15;144(4):1544] COMMENT The allelic variations within classical HLA-DR antigens are mostly confined to the amino-terminal domain of beta 1 protein encoded for by the exon-2 of the DRB1 gene. FEATURES Location/Qualifiers source 1..266 /organism="Homo sapiens" /db_xref="taxon:9606" Region 1..29 /region_name="domain" /note="signal sequence" Protein 1..266 /product="MHC class II histocompatibility antigen HLA-DR beta 1 chain DR16 precursor" Region 30..266 /region_name="product" /note="MHC class II histocompatibility antigen HLA-DR beta 1 chain DR16" ORIGIN 1 MVCLK LPGGS CMTAL TVTLM VLSSP LALAG DTRPR FLWQP KRECH FFNGT 51 ERVRF LDRYF YNQEE SVRFD SDVGE YRAVT ELGRP DAEYW NSQKD LLEDR 101 RAAVD TYCRH NYGVG ESFTV QRRVQ PKVTV YPSKT QPLQH HNLLV CSVSG 151 FYPGS IEVRW FLNGQ EEKAG MVSTG LIQNG DWTFQ TLVML ETVPR SGEVY 201 TCQVE HPSVT SPLTV EWRAR SESAQ SKMLS GVGGF VLGLL FLGAG LFIYF 251 RNQKG HSGLQ PTGFL S //